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The University of California, Berkeley
The University of California, Berkeley is the highest ranked public university in the U.S. and the 4th-ranked academic institution in the world (2011 Shanghai Academic Ranking of World Universities). The excellence of the Berkeley faculty has produced a long history of innovative research and has motivated collaborations with investigators throughout the world. Indeed, much of the current motivation to develop the exposome concept can be traced to the seminal work of Berkeley faculty members Stephen Rappaport and Martyn Smith.
Role in the project
Professor Rappaport contributes to WP6, which will perform untargeted analysis of all adducts (adductomics) in selected samples of human serum albumin (HSA) from European populations exposed to different levels of air and water pollution. Much of the effort will be devoted to assisting Kings College, London to apply Rappaport’s mass spectrometric methodology for characterizing HSA adductomes.
Professor Smith contributes to WP10 which will integrate and disseminate the most relevant results from other WPs. He works with IARC to: (a) reduce the uncertainty of risk assessment, (b) define risks due to air pollution and water contamination, (c) identify new risks from applications of untargeted omics to human biospecimens and (d) refine knowledge about the burden of particular diseases associated with selected exposures.
Key persons to be involved
| Name | Expertise | Role in the project |
| Professor Stephen M. Rappaport | Exposure biology, measurement of protein adducts, exposure assessment, human metabolism of toxic chemicals, and statistical models of human exposure |
Collaborator in characterizing blood protein adducts, transfer methodology for adduct measurements, supervisor of high-resolution mass spectrometry |
| Professor Martyn T. Smith | Causes of leukemia and lymphoma, metabolism and toxicity of benzene, applying ‘Omic’ technologies to develop biomarkers of exposure, early effect and susceptibility in humans |
Coolaborator in exploiting the exposome concept in improving methods for assessing exposures to toxic chemicals |
| Dr He (Harry) Li | Biochemistry, mass spectrometry of protein adducts |
High resolution mass spectrometry of selected samples |
